What are the parameters for intervention for a patient with mixed aortic valve disease?

If you haven’t already read the two attached papers, I strongly recommend doing so – my takeaway is that we should be more aggressive about treating mod AI + mod AS than we traditionally have been.

Central Illustration. Moderate Mixed Aortic Valve Disease: AE Rates


Egbe AC, Luis SA, Ratnasari Padang, Warnes CA. Outcomes in Moderate Mixed Aortic Valve Disease. Journal of the American College of Cardiology. 2016;67(20):2321-2329. doi:https://doi.org/10.1016/j.jacc.2016.03.509

Philip JL, Zens T, Lozonschi L, et al. Outcomes of surgical aortic valve replacement for mixed aortic valve disease. Journal of Thoracic Disease. 2018;10(7). doi:https://doi.org/10.21037/jtd.2018.06.128

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Should patients with mechanical prosthetic valves take a baby aspirin?

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Do we give aspirin to someone s/p bioprosthetic SAVR if she is already on apixaban for unprovoked DVT?